Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension

Abstract Background Hypoxic pulmonary hypertension (HPH) is a chronic progressive advanced disorder pathologically characterized by pulmonary vascular remodeling. Notch4 as a cell surface receptor is critical for vascular development. However, little is known about the role and mechanism of Notch4 i...

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Bibliografski detalji

Glavni autori:	Mingzhou Guo, Mengzhe Zhang, Xiaopei Cao, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Jianping Zhao, Yongjian Xu, Xiansheng Liu, Xiaochen Li
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2022-01-01
Serija:	Respiratory Research
Teme:	Hypoxic pulmonary hypertension Human pulmonary arterial smooth muscle cells Notch4 Mitogen-activated protein kinase
Online pristup:	https://doi.org/10.1186/s12931-022-01927-9
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