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Severe Hyperprolactinemia Promotes Brown Adipose Tissue Whitening and Aggravates High Fat Diet Induced Metabolic Imbalance

BackgroundThe association of high serum prolactin and increased body weight is positive but controversial, therefore we hypothesized that additional factors such as diets and the impact of prolactin on brown adipose tissue may condition its metabolic effects.MethodsWe used LacDrd2KO females with lif...

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Principais autores: Felicitas Lopez-Vicchi, Catalina De Winne, Ana Maria Ornstein, Eleonora Sorianello, Judith Toneatto, Damasia Becu-Villalobos
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-06-01
Serier:Frontiers in Endocrinology
Fag:
prolactin
brown adipose tissue
thermogenic markers
whitening
UCP1
PGC1 alpha
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2022.883092/full
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