Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA

mRNA is a blooming technology for vaccination and has gained global attention during the SARS-CoV-2 pandemic. However, the recent clinical trials have highlighted increased reactogenicity when using high mRNA doses. Intending to increase the potency of mRNA therapeutics and to decrease the therapeut...

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Bibliografske podrobnosti

Principais autores:	Sergio Linares-Fernández, Julien Moreno, Elise Lambert, Perrine Mercier-Gouy, Laetitia Vachez, Bernard Verrier, Jean-Yves Exposito
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2021-12-01
Serija:	Molecular Therapy: Nucleic Acids
Teme:	mRNA translation efficiency mRNA untranslated sequence dsRNA dendritic cells mRNA-LNP complex zebrafish injection
Online dostop:	http://www.sciencedirect.com/science/article/pii/S216225312100250X
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