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Comparison of intranasal naloxone and intranasal nalmefene in a translational model assessing the impact of synthetic opioid overdose on respiratory depression and cardiac arrest

IntroductionUsing a validated translational model that quantitatively predicts opioid-induced respiratory depression and cardiac arrest, we compared cardiac arrest events caused by synthetic opioids (fentanyl, carfentanil) following rescue by intranasal (IN) administration of the μ-opioid receptor a...

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Autori principali: Celine M. Laffont, Prasad Purohit, Nash Delcamp, Ignacio Gonzalez-Garcia, Phil Skolnick
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-06-01
Serie:Frontiers in Psychiatry
Soggetti:
synthetic opioids
fentanyl
carfentanil
cardiac arrest
translational model
opioid antagonists
Accesso online:https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1399803/full
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