Control of 11-Aza:4-X-SalA Cocrystal Polymorphs Using Heteroseeds That Switch On/Off Halogen Bonding

A family of: 1:1 cocrystals 11-Aza:4-X-SalA have been prepared from the potent anti-malarial compound 11-azaartemisinin with 4-halosalicylic acids. When X = 4-Cl, 4-Br and 4-I, two conformational polymorphs can be isolated in each case. Monoclinic type-I was found previously for parent 11-Aza:SalA (...

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Auteurs principaux:	Keyao Li, Monalisa Roy, Madiha Nisar, Lawrence W-Y. Wong, Herman H-Y. Sung, Richard K. Haynes, Ian D. Williams
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-09-01
Collection:	Crystals
Sujets:	cocrystal polymorph hetero-seeding liquid assisted grinding (LAG) artemisinin anti-malarial drugs
Accès en ligne:	https://www.mdpi.com/2073-4352/12/10/1368
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