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LncRNA HOTAIR induces sunitinib resistance in renal cancer by acting as a competing endogenous RNA to regulate autophagy of renal cells

Abstract Background Cell autophagy has been proposed to be involved in drug resistance therapy. However, how the long non-coding RNA (lncRNA) reduces risks of drug resistance in renal cancer (RC) cells needs a thorough inquiry. This study was assigned to probe the effect and mechanism of HOTAIR on s...

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Main Authors: Dechao Li, Changfu Li, Yongsheng Chen, Lichen Teng, Yan Cao, Wentao Wang, Hongxin Pan, Yongpeng Xu, Dan Yang
Format: Artigo
Language:Inglês
Published: BMC 2020-07-01
Series:Cancer Cell International
Subjects:
HOTAIR
Sunitinib
miR-17-5p
Beclin1
Renal cancer
Autophagy
Online Access:http://link.springer.com/article/10.1186/s12935-020-01419-0
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