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The metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit

Abstract The PI3K pathway is one of the most deregulated pathways in cancer, which is predominantly due to gain of function mutations or altered expression of the PI3KCA gene. This is codified by what is seen for the class I PI3K catalytic subunit p110α, a common feature of many cancers. The metasta...

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Ngā kaituhi matua: Francesco Paolo Pennino, Masanao Murakami, Massimo Zollo, Erle S. Robertson
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Publishing Group 2021-04-01
Rangatū:Oncogenesis
Urunga tuihono:https://doi.org/10.1038/s41389-021-00326-x
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