Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.

The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 degrade host hemoglobin to provide free amino acids for parasite protein synthesis. Hemoglobin hydrolysis has been described as an ordered process initiated by aspartic proteases, but cysteine protease inhibitors completely blo...

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Autors principals:	Shoba Subramanian, Markus Hardt, Youngchool Choe, Richard K Niles, Eric B Johansen, Jennifer Legac, Jiri Gut, Iain D Kerr, Charles S Craik, Philip J Rosenthal
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2009-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC2663817?pdf=render
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