Clonal hematopoiesis of indeterminate potential and cardiovascular disease: mechanistic insights, clinical implications, and the dawn of precision cardio-hematology

Clonal hematopoiesis of indeterminate potential (CHIP) has substantially advanced our understanding of cardiovascular pathogenesis by demonstrating how somatic mutations in hematopoietic stem cells amplify the bone marrow–heart axis to accelerate atherosclerosis and heart failure, building upon the...

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Principais autores:	Hong Wu, Xinyi Meng, Long Li, Chao Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Cardiovascular Medicine
Assuntos:	atherosclerosis CHIP clonal hematopoiesis of indeterminate potential DNMT3A heart failure inflammation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcvm.2026.1796328/full
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