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Therapeutic genetic variation revealed in diverse Hsp104 homologs

The AAA+ protein disaggregase, Hsp104, increases fitness under stress by reversing stress-induced protein aggregation. Natural Hsp104 variants might exist with enhanced, selective activity against neurodegenerative disease substrates. However, natural Hsp104 variation remains largely unexplored. Her...

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Principais autores: Zachary M March, Katelyn Sweeney, Hanna Kim, Xiaohui Yan, Laura M Castellano, Meredith E Jackrel, JiaBei Lin, Edward Chuang, Edward Gomes, Corey W Willicott, Karolina Michalska, Robert P Jedrzejczak, Andrzej Joachimiak, Kim A Caldwell, Guy A Caldwell, Ophir Shalem, James Shorter
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2020-12-01
coleção:eLife
Assuntos:
disaggregase
chaperone
Hsp104
protein misfolding
TDP-43
alpha-synuclein
Acesso em linha:https://elifesciences.org/articles/57457
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