Tumour-associated high endothelial venules drive portal-specific immune evasion in lymph nodes via ALOX12

Abstract High endothelial venules (HEVs) provide another portal for tumour metastasis. However, whether HEVs and other blood vessels exert different effects on tumour escape remains unknown. Here we show that tumour involvement in HEVs is an independent prognostic marker for patients with lymph node...

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Autors principals:	Qidong Xia, Jiayao Pan, Xiaoqi Weng, Shunrong Li, Jiaqian Li, Shijian Song, Jiang Li, Boxuan Zhou, Xinwei Liu, Dong-Ming Kuang, Nu Zhang, Jin Jin, Jinting Liu, Zhen Lin, Shubin Yu, Qionglan Tang, Lijuan Bian, Yunjie Zeng, Yu Shi, Yiqing Zheng, Jian-You Liao, Shouping Xu, Shicheng Su
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-05-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-72412-w
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