Structural and mechanistic insights into α2β1 and α5β1 integrin targeting by bioengineered extracellular vesicles originating from lung cancer cells

Abstract Integrins are transmembrane receptors that mediate bidirectional signaling across the plasma membrane and play a crucial role in tumor progression, metastasis, and cellular communication. In this study, we performed a comparative structural and biophysical analysis of the PTHTRWA-functional...

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Principais autores:	Anna M. Nowicka, Teresa Żołek, Agata Kowalczyk, Ireneusz P. Grudzinski
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-03-01
Series:	Scientific Reports
Assuntos:	Integrins α2β1 and α5β1 Lung cancer–derived extracellular vesicles Molecular dynamics simulations Ligand-induced conformational changes in integrins Binding affinity of the PTHTRWA-EVs-integrin complex
Acceso en liña:	https://doi.org/10.1038/s41598-026-46071-2
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