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Defying c-Abl signaling circuits through small allosteric compounds

Many extracellular and intracellular signals promote the c-Abl tyrosine kinase activity. c-Abl in turn triggers a multitude of changes either in protein phosphorylation or in gene expression in the cell. Yet, c-Abl takes part in diverse signaling routes because of several domains linked to its catal...

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Hlavní autor: Stefania eGonfloni
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014-11-01
Edice:Frontiers in Genetics
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On-line přístup:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00392/full
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