Exploring the activity of a novel orally bioavailable β-lactam-β-lactamase inhibitor combination, ceftibuten-ledaborbactam, against Enterobacterales-carrying blaOXA-48

ABSTRACT Ledaborbactam is a novel boronic-acid inhibitor of class A, C, and D β-lactamases, including OXA-48, being developed in combination with ceftibuten. Herein, we examined the in vitro activity of this combination vs. other orally bioavailable compounds against 50 Enterobacterales-carrying bla...

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Auteurs principaux:	Maria F. Mojica, Elise T. Zeiser, Scott A. Becka, David A. Six, Greg Moeck, Robert A. Bonomo, Krisztina M. Papp-Wallace
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2026-02-01
Collection:	Microbiology Spectrum
Sujets:	β-lactamases Enterobacterales β-lactam OXA-48 carbapenemase β-lactamase inhibitor
Accès en ligne:	https://journals.asm.org/doi/10.1128/spectrum.03148-25
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