TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis
The transcription factor p63 guards genome integrity in the female germline, and its mutations have been reported in patients with premature ovarian insufficiency (POI). However, the precise contribution of the TP63 gene to the pathogenesis of POI needs to be further determined. Here, in 1,030 Chine...
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| Автори: | , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Society for Clinical Investigation
2023-03-01
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| Серія: | The Journal of Clinical Investigation |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1172/JCI162315 |
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