Lactate and lactylation: mechanisms, function, diseases, and therapeutic targets

Abstract The paradigm shift of lactate from a mere metabolic byproduct to a pleiotropic signaling molecule, coupled with the discovery of lactylation, provides a crucial framework for understanding how metabolic reprogramming drives systemic pathology. In this review, we systematically delineate the...

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Prif Awduron:	Xiuping Wang, Cheng Liu, Yue Chen, Yuqing Fang, Jingyi Li, Yu Liu, Yu Pan, Suya Bao, Xiwen Wang, Yi Liu, Hengwei Liu
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Springer 2026-05-01
Cyfres:	Molecular Biomedicine
Pynciau:	Lactate metabolism Lactylation Post-translational modifications Metabolic reprogramming Epigenetic regulation
Mynediad Ar-lein:	https://doi.org/10.1186/s43556-026-00472-x
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!