Ecteinascidin synthetic analogues: a new class of selective inhibitors of transcription, exerting immunogenic cell death in refractory malignant pleural mesothelioma

Abstract Background Malignant pleural mesothelioma (MPM) is a highly chemo-refractory and immune-evasive tumor that presents a median overall survival of 12–14 months when treated with chemotherapy and immunotherapy. New anti-tumor therapies as well as the concomitant reactivation of immune destruct...

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Главные авторы:	I. C. Salaroglio, P. Aviles, J. Kopecka, A. Merlini, F. Napoli, L. Righi, S. Novello, H. Sullivan, C. Cuevas, G. V. Scagliotti, C. Riganti
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-12-01
Серии:	Journal of Experimental & Clinical Cancer Research
Предметы:	Malignant pleural mesothelioma Ecteinascidins DNA damage Immunogenic cell death cGAS/STING pathway Chemo-immunotherapy
Online-ссылка:	https://doi.org/10.1186/s13046-024-03253-y
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