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Allele-specific methylation occurs at genetic variants associated with complex disease.

We hypothesize that the phenomenon of allele-specific methylation (ASM) may underlie the phenotypic effects of multiple variants identified by Genome-Wide Association studies (GWAS). We evaluate ASM in a human population and document its genome-wide patterns in an initial screen at up to 380,678 sit...

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Main Authors: John N Hutchinson, Towfique Raj, Jes Fagerness, Eli Stahl, Fernando T Viloria, Alexander Gimelbrant, Johanna Seddon, Mark Daly, Andrew Chess, Robert Plenge
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4049588?pdf=render
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