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Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma

Abstract Background Pilomyxoid astrocytomas are an aggressive subtype of astrocytoma, not graded by WHO, frequently located in hypothalamic/chiasmatic region, affecting diencephalic structures, and characterized by shorter survival and high recurrence rates. Pilomyxoid astrocytoma management remains...

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Principais autores: Elena I. Fomchenko, Benjamin C. Reeves, William Sullivan, Asher M. Marks, Anita Huttner, Kristopher T. Kahle, E. Zeynep Erson‐Omay
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2021-02-01
Serier:Molecular Genetics & Genomic Medicine
Fag:
FGFR inhibitor resistance
FGFR1 mutation
FGFR1 p.K656E
FGFR1 p.V561M
pilomyxoid astrocytoma
whole exome sequencing
Online adgang:https://doi.org/10.1002/mgg3.1597
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