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Compact SchCas9 Recognizes the Simple NNGR PAM

Abstract Clustered regularly interspaced short palindromic repeat (CRISPR)/SaCas9 is the most popular tool for in vivo genome editing due to its high efficiency and small genome. The authors previously developed four SaCas9 orthologs as genome‐editing tools. Here, to expand the targeting scope, they...

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Principais autores: Shuai Wang, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi, Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu, Renjie Chai, Yongming Wang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2022-02-01
Serier:Advanced Science
Fag:
CRISPR/Cas9
genome editing
PAM
SaCas9
SchCas9
Online adgang:https://doi.org/10.1002/advs.202104789
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