Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response.
Cyclic GMP-AMP synthase (cGAS) senses viral DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the ER-localized adaptor protein Mediator of IRF3 Activator (MITA) to initiate innate antiviral response. Human cytomegalovirus (HCMV) proteins can antagonize ho...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science (PLoS)
2019-05-01
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| Collection: | PLoS Pathogens |
| Accès en ligne: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007691&type=printable |
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