The Janus Kinase Inhibitor Ruxolitinib Prevents Terminal Shock in a Mouse Model of Arenavirus Hemorrhagic Fever

Arenaviruses such as Lassa virus cause arenavirus hemorrhagic fever (AVHF), but protective vaccines and effective antiviral therapy remain unmet medical needs. Our prior work has revealed that inducible nitric oxide synthase (iNOS) induction by IFN-γ represents a key pathway to microvascular leak an...

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Hlavní autoři:	Mehmet Sahin, Melissa M. Remy, Doron Merkler, Daniel D. Pinschewer
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-03-01
Edice:	Microorganisms
Témata:	Arenavirus hemorrhagic fever LCMV Janus kinase JAK inhibitor Ruxolitinib nitric oxide
On-line přístup:	https://www.mdpi.com/2076-2607/9/3/564
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