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Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap

(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was assigned to severity. (2) Methods: We expressed AQP...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Katharina Geistlinger, Jana D. R. Schmidt, Eric Beitz
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-01-01
Schriftenreihe:Life
Schlagworte:
aquaglyceroporin
monocarboxylate transporter
<span style="font-variant: small-caps">l-</span>lactic acid
<span style="font-variant: small-caps">l-</span>lactate
proton
gradient
Online-Zugang:https://www.mdpi.com/2075-1729/12/1/120
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