Single dose of 5 Gy can damage erythrocytes and consequently induces lymphocyte depletion in spleen and circulating blood

PurposeRadiation-induced lymphopenia (RIL) has been well known to associate with poor patient prognosis. Based on interesting findings in our previous study, we hypothesize that a low dose of 5-Gy can damage erythrocytes, which indirectly depletes lymphocytes in spleen, and may contribute to RIL. Th...

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Principais autores:	Peimeng You, Xiaohang Qin, Yinghui Li, Huiling Ye, Yuhui Zhao, Guangshan Wang, Cuimeng Tian, Shuo Yin, Junyu Li, Teng Ma, Feng-Ming (Spring) Kong, Jian-Yue Jin
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2026-06-01
סדרה:	Frontiers in Immunology
נושאים:	erythrocyte damage hemosiderin-laden macrophages immune microenvironment radiation-induced lymphopenia splenic clearance
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1848576/full
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