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Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade

Abstract Background Podocytes have become a crucial target for interventions in proteinuric kidney diseases. Many studies have reported that overexpression of transient receptor potential cation channel protein 6 (TRPC6) in podocyte injury upregulates intracellular Ca2+ influx and stimulates Ca2+-de...

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Principais autores: Yin Ding, Xuanli Tang, Yuhui Wang, Dongrong Yu, Caifeng Zhu, Jin Yu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-12-01
Serier:BMC Complementary Medicine and Therapies
Fag:
Tetrandrine
Podocyte injury
Transient receptor potential cation channel protein 6
Calpain-1
Online adgang:https://doi.org/10.1186/s12906-021-03469-x
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