The potential role of aberrant microglial synaptic pruning in the neurodevelopmental pathogenesis of tourette syndrome

Tourette syndrome is a neurodevelopmental disorder traditionally attributed to dopamine system hyperactivity within the cortico-striato-thalamo-cortical circuitry. However, classical neurotransmitter hypotheses fail to fully explain the spatiotemporal and developmental specificities of the disorder....

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Detalhes bibliográficos

Principais autores:	Lu Lu, Yuxuan Zang, Caiwei Song, Yan Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-07-01
coleção:	Frontiers in Neuroscience
Assuntos:	basal ganglia circuitry microglia nanomedicine neuroimmune microenvironment synaptic pruning tourette syndrome
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2026.1895330/full
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