Cross-national pharmacovigilance of drug-induced intestinal obstruction: disproportionality signals in FAERS and external validation in JADER

Using deduplicated FAERS reports from Q1 2004 to Q4 2024 (18,532,100 unique reports), we identified 62,919 cases of drug-induced intestinal obstruction (DIO) and prioritised the 50 suspect drugs with the highest DIO report counts. Disproportionality screening using both the reporting odds ratio (ROR...

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Autores principales:	Yang Liu, Shengde Wu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Colección:	Frontiers in Pharmacology
Materias:	drug-induced intestinal obstruction FAERS JADER pharmacovigilance real-world evidence reporting odds ratio
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1760208/full
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