Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis

Background: Malignancies with BRCA1/2 deficiencies are particularly sensitive to PARP inhibitors. Thus, combining PARP inhibitors with agents that impair DNA damage repair to treat BRCA1/2 wild-type PDAC could broaden the clinical use of these promising PARP inhibitors. Here we examined the synergis...

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Principais autores:	Chu-di Zhang, Li-hong Jiang, Xue Zhou, Yong-ping He, Ye Liu, Dong-ming Zhou, Yao Lv, Ben-qing Wu, Zheng-yan Zhao
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2024-01-01
Serija:	Translational Oncology
Teme:	Pancreatic cancer Recombinant Chinese Hu191 measles virus Olaparib Oxidative DNA damage ROS Apoptosis
Online dostop:	http://www.sciencedirect.com/science/article/pii/S1936523323001985
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