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Cerebrospinal fluid sclerostin levels in the early Alzheimer's disease stages

Abstract INTRODUCTION Sclerostin, a negative regulator of bone formation, has been involved in memory impairment in Alzheimer's disease (AD) mouse models and is increased in elderly people at risk of AD. Here, we investigated sclerostin's role across the clinical stages of AD. METHODS We evaluated c...

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Autori principali: Manuela Dicarlo, Patrizia Pignataro, Daniele Urso, Chiara Zecca, Maria Teresa Dell'Abate, Francesco Borlizzi, Valentina Gnoni, Alessia Giugno, Angela Oranger, Graziana Colaianni, Roberta Zerlotin, Clelia Suriano, Silvia Colucci, Giancarlo Logroscino, Maria Grano
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2026-01-01
Serie:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Soggetti:
Alzheimer's disease
amyloid beta
dementia
mild cognitive impairment
neurodegeneration
phosphorylated tau
Accesso online:https://doi.org/10.1002/dad2.70297
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