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miR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis

Abstract Background This article aims to reveal the therapeutic effects and potential mechanisms of bone mesenchymal stem cell (BMSC)-derived exosomes on premature ovarian failure (POF). Methods Exosomes were collected from BMSCs and were used to treat cisplatin-induced POF mouse models. Pathologica...

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Autori principali: Bo Sun, Yujia Ma, Fang Wang, Linli Hu, Yingpu Sun
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-11-01
Serie:Stem Cell Research & Therapy
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Accesso online:https://doi.org/10.1186/s13287-019-1442-3
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