Increased glycoprotein hormone yield in stably transfected CHO cells using human serum albumin signal peptide for beta-chains

Heterologous signal peptides enable increasing titers of recombinant proteins in mammalian cell culture. Four human heterodimeric glycoprotein hormones (follicle-stimulating hormone, FSH; luteinizing hormone, LH; chorionic gonadotropin, CG; and thyroid-stimulating hormone, TSH) were expressed in sta...

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Hauptverfasser:	Maria V. Sinegubova, Denis E. Kolesov, Ivan I. Vorobiev, Nadezhda A. Orlova
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	PeerJ Inc. 2025-02-01
Schriftenreihe:	PeerJ
Schlagworte:	Glycoprotein hormones Gonadotropins Human follicle stimulating hormone (hFSH) Human luteinizing hormone (hLH) Human chorionic gonadotropin (hCG) Human thyroid stimulating hormone (hTSH)
Online-Zugang:	https://peerj.com/articles/18908.pdf
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