Dimethyl itaconate suppresses dendritic cell and CD8+ T cell responses to halt vitiligo

Abstract Background Although dendritic cell (DC)- and CD8+ T cell-mediated autoimmunity is critical for destroying melanocytes in vitiligo, treatment options remain limited by the absence of therapies that cotarget both cell types. Methods We first evaluated the association between the immunoregulat...

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Bibliografiske detaljer

Principais autores:	Yinghan Wang, Yuhan Chen, Jingjing Ma, Linxuan Wu, Pan Kang, Jianru Chen, Pengran Du, Wei Wu, Xinju Wang, Kaiqiao He, Yuqi Yang, Sen Guo, Weinan Guo, Ling Liu, Zhe Jian, Tianwen Gao, Shuli Li, Chunying Li
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2025-12-01
Serier:	BMC Medicine
Fag:	Autoimmune disease CD8+ T cell Dendritic cell Dimethyl itaconate JAK-STAT pathway Vitiligo
Online adgang:	https://doi.org/10.1186/s12916-025-04512-1
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