Characterization of KLK5-high epithelial cells and their interactions with the tumor microenvironment in high-grade serous ovarian cancer

Abstract Ovarian cancer remains a significant global health burden, with high-grade serous ovarian cancer (HGSOC) representing the most lethal subtype. Bulk RNA-seq analysis revealed KLK5 (Kallikrein-5, a serine protease) upregulation in ovarian cancer, correlating with shortened disease-free surviv...

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Principais autores:	Zhe Wang, Longkun Ding, Qingwei Zhu, Qingjian Ou, Qi Wang, Ying Xie, Li Li, Xuan Liu, Chenghao Ni, Yufeng Wang, Yonghe Liu, Liting Yu, Jiahui Cai, Lu Gao
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-03-01
Serija:	Cancer Cell International
Teme:	Single-cell and spatial transcriptomics HGSOC (High-Grade Serous Ovarian Cancer) Epithelial-stromal crosstalk ECM remodeling Tumor Microenvironment (TME) KLK5 (Kallikrein-5)
Online dostop:	https://doi.org/10.1186/s12935-026-04273-8
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