Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects

Abstract Gestational diabetes mellitus (GDM) affects ~14% of pregnancies and increases maternal type 2 diabetes mellitus (T2DM) risk. The GenDiP Consortium presents trans-generational, multi-ancestry genome-wide association study meta-analyses of GDM and pregnancy glycemic traits in up to 38,305 GDM...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Caroline Brito Nunes, Valentina Rukins, Aminata H. Cisse, Frédérique White, Nancy McBride, Alan Kuang, Catherine Allard, Justiina Ronkainen, Alice Hughes, Amanda Elliott, Gudmar Thorleifsson, Marc Vaudel, Triin Laisk, Yuqin Gu, Amel Lamri, Li Chen, Johanna Tuhkanen, Jari Lahti, Lucinda Calas, Manon Muntaner, Ville Karhunen, Jaewon Choi, Anni Heiskala, Gad Hatem, Nicolas Fragoso-Bargas, Sheryl L. Rifas-Shiman, Guillermo Paz-Lopez, Sara E. Stinson, Bishwajit Bhowmik, Emma Ahlqvist, Estonian Biobank Research Team, Genes & Health Research Team, Jean-Francois Deleuze, Johan G. Eriksson, Jongseok Park, Koon Teo, Katri Räikkönen, Kari Stefansson, Maria Molina-Vega, Padmaja Subbarao, Robin N. Beaumont, Stefan Johansson, Tiinamaija Tuomi, Torben Hansen, Line Engelbrechtsen, Sonsoles Morcillo, Emily Oken, Elisabeth Quigstad, Kåre I. Birkeland, Marja Vääräsmäki, Andrew T. Hattersley, Sylvain Sebert, Graham A. Hitman, Soo Heon Kwak, Marjo-Riitta Järvelin, Rashmi B. Prasad, Barbara Heude, Aline Meirhaeghe, Luigi Bouchard, Pierre-Étienne Jacques, Hannele Laivuori, Kok Hian Tan, Sonia S. Anand, David A. van Heel, Siyang Liu, Pål R. Njølstad, Valgerdur Steinthorsdottir, Elisabeth Widén, Elina Keikkala, Denise M. Scholtens, William L. Lowe, Sarah Finer, Andrew P. Morris, Reedik Mägi, Julia Zöllner, Maria Carolina Borges, Deborah A. Lawlor, Marie-France Hivert, Rachel M. Freathy, David M. Evans, Gunn-Helen Moen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-06-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-026-73509-y
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!