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Cell Mass Increase Associated with Formation of Glucose‐Controlling β‐Cell Mass in Device‐Encapsulated Implants of hiPS‐Derived Pancreatic Endoderm

Abstract Device‐encapsulated human stem cell‐derived pancreatic endoderm (PE) can generate functional β‐cell implants in the subcutis of mice, which has led to the start of clinical studies in type 1 diabetes. Assessment of the formed functional β‐cell mass (FBM) and its correlation with in vivo met...

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Principais autores: Thomas Robert, Ines De Mesmaeker, Freya O. Van Hulle, Krista G. Suenens, Geert M. Stangé, Zhidong Ling, Corinne Haller, Nicolas Bouche, Bart Keymeulen, Marine R.C. Kraus, Daniel G. Pipeleers
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019-12-01
Serier:Stem Cells Translational Medicine
Fag:
Diabetes
Induced pluripotent stem cells
Pancreatic differentiation
Cell transplantation
Progenitor cells
Online adgang:https://doi.org/10.1002/sctm.19-0043
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