Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts

Abstract Master transcription factors (MTFs) are key regulators in cell fate determination. However, an approach to profile MTF’s direct transcriptional targets together with their associated RNA-binding proteins (RBPs), is still lacking. Here, we applied 5-ethynyluridine RNA metabolic labeling and...

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Hlavní autoři:	Mingqiang Deng, Dongmei He, Xiwei Wang, Yuting Yuan, Lishen Wang, Yanlin Hou, Qiuyue Zhu, Chuanman Zhou, Zhibiao Mai, Yulong Zhang, Zhengwen Nie, Yuling Song, Qiongfang Wu, Luyao Pan, Bei Dong, Zhi Xiong, Duo Li, Dongjun Liu, Jinxin Xu, Dajiang Qin, Hui Zheng, Yu Zhao, Peng Tang, Jinkai Wang, Cristin Print, Ralf Jauch, Wensheng Zhang, Guangming Wu, Xichen Bao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-12-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-025-67018-7
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