Polymorphisms in Manganese Transporters SLC30A10 and SLC39A8 Are Associated With Children's Neurodevelopment by Influencing Manganese Homeostasis

Background: Manganese (Mn) is an essential element but at excessive levels, it is neurotoxic. Even a moderate increase in Mn has been suggested to interfere with neurodevelopment in children. Genetics influencing Mn concentrations and toxicity is unclear.Objective: We assessed, in a cross-sectional...

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Auteurs principaux:	Karin E. Wahlberg, Stefano Guazzetti, Daniela Pineda, Susanna C. Larsson, Chiara Fedrighi, Giuseppa Cagna, Silvia Zoni, Donatella Placidi, Robert O. Wright, Donald R. Smith, Roberto G. Lucchini, Karin Broberg
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2018-12-01
Collection:	Frontiers in Genetics
Sujets:	manganese neurotoxicity neurodevelopment ADHD SLC30A10 SLC39A8
Accès en ligne:	https://www.frontiersin.org/article/10.3389/fgene.2018.00664/full
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