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Intracellular Delivery of siRNAs Targeting AKT and ERBB2 Genes Enhances Chemosensitization of Breast Cancer Cells in a Culture and Animal Model

Pharmacotherapy as the mainstay in the management of breast cancer suffers from various drawbacks, including non-targeted biodistribution, narrow therapeutic and safety windows, and also resistance to treatment. Thus, alleviation of the constraints from the pharmacodynamic and pharmacokinetic profil...

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Principais autores: Tahereh Fatemian, Hamid Reza Moghimi, Ezharul Hoque Chowdhury
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2019-09-01
Serier:Pharmaceutics
Fag:
siRNA
drug delivery
nanoparticle
carbonate apatite
ERBB2
AKT
breast cancer
Online adgang:https://www.mdpi.com/1999-4923/11/9/458
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