Group a Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination

ABSTRACT Group A Streptococcus (GAS) is a major human pathogen that causes several invasive diseases including necrotizing fasciitis. The host coagulation cascade initiates fibrin clots to sequester bacteria to prevent dissemination into deeper tissues. GAS, especially skin-tropic bacterial strains,...

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Detalhes bibliográficos

Principais autores:	Henry M. Vu, Thomas E. Moran, Zhong Liang, Yun-Juan Bao, Paulina G. Carles, Jessica C. Keane, Madelyn G. Cerney, Caitlyn N. Dahnke, Ana L. Flores-Mireles, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-02-01
coleção:	Microbiology Spectrum
Assuntos:	plasminogen RNA-seq fibrin Streptococcus pyogenes host-pathogen dynamics live imaging microscopy
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.02607-24
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