Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (<i>Lrrk1</i>) gene were osteopetrotic due to the failure of osteoclasts to resorb bone. To determine how LRRK1 regulates osteoclast activity, we examined the intracellular and extracellular acidification...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
MDPI AG
2023-03-01
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| Серии: | Biology |
| Предметы: | |
| Online-ссылка: | https://www.mdpi.com/2079-7737/12/4/511 |
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