Molecular Docking, ADMET Study, Synthesis, Characterization and Preliminary Antiproliferative Activity of Potential Histone Deacetylase Inhibitors with Isoxazole as New Zinc Binding Group
Histone acetylation is a highly interesting epigenetic target for drug therapy. Histone deacetylase enzymes (HDACs) are overexpressed in several diseases, including cancers. Most of the clinically used HDAC inhibitors involve hydroxamate group as a zinc-binding group (ZBG). Hydroxamates have a poor...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
College of Pharmacy University of Baghdad
2023-11-01
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| シリーズ: | Iraqi Journal of Pharmaceutical Sciences |
| 主題: | |
| オンライン･アクセス: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1919 |
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