An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins

Abstract The AAA protease FtsH associates with HflK/C subunits to form a megadalton-size complex that spans the inner membrane and extends into the periplasm of E. coli. How this bacterial complex and homologous assemblies in eukaryotic organelles recruit, extract, and degrade membrane-embedded subs...

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Principais autores:	Alireza Ghanbarpour, Bertina Telusma, Barrett M Powell, Jia Jia Zhang, Isabella Bolstad, Carolyn Vargas, Sandro Keller, Tania A Baker, Robert T Sauer, Joseph H Davis
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer Nature 2025-03-01
Series:	The EMBO Journal
Assuntos:	Cryo-EM Proteostasis AAA Protease Macromolecular Complexes
Acceso en liña:	https://doi.org/10.1038/s44318-025-00408-1
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