Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

Signaling pathways of VEGFs and PDGFs are crucial in tumor angiogenesis, which is essential in solid tumor progression and metastasis. This study reports our strategy for designing and synthesizing a series of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential m...

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Váldodahkkit:	Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang, An-Rong Lee
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2017-05-01
Ráidu:	Molecules
Fáttát:	multi-target kinase inhibitor VEGFR-2 inhibitor PDGFRβ inhibitor angiogenesis (2-oxoindolin-3-ylidene)methylpyrrole
Liŋkkat:	http://www.mdpi.com/1420-3049/22/6/913
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