Genomic Instability and Adaptive Evolution Induced by RFA Insufficiency in <i>Saccharomyces cerevisiae</i>

This study systematically investigated the genomic alterations in <i>Saccharomyces cerevisiae</i> driven by Replication Factor A (RFA) dosage insufficiency using a promoter-replacement strategy combined with mutation accumulation and whole-genome sequencing. Our findings reveal that transcriptional...

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Autori principali:	Runbiao Zhang, Liyan Tian, Min He, Kejing Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-01-01
Serie:	Current Issues in Molecular Biology
Soggetti:	genomic stability Replication Factor A mismatch repair DNA replication replication stress
Accesso online:	https://www.mdpi.com/1467-3045/48/2/158
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