Preparation and Optimization of Triptolide-Loaded Solid Lipid Nanoparticles for Oral Delivery with Reduced Gastric Irritation

Triptolide (TP) often causes adverse reactions in the gastrointestinal tract when it is administered orally. This study aimed to prepare and optimize triptolide-loaded solid lipid nanoparticles (TP-SLN) with reduced gastric irritation. The microemulsion technique was used to formulate TP-SLN employi...

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Bibliografische Detailangaben

Hauptverfasser:	Xiangliang Yang, Christopher Waikei Lam, Huibi Xu, Wei Liu, Jiangling Wan, Fan Peng, Cong Zhang, Conghui Gu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2013-10-01
Schriftenreihe:	Molecules
Schlagworte:	triptolide solid lipid nanoparticles microemulsion technique central composite design sustained release gastric irritation
Online-Zugang:	http://www.mdpi.com/1420-3049/18/11/13340
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