Pioglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, Downregulates the Inflammatory Response in Cutaneous Leishmaniasis Patients Without Interfering in Leishmania braziliensis Killing by Monocytes

Patients with cutaneous leishmaniasis (CL) due to Leishmania braziliensis infection have an exacerbated inflammatory response associated with tissue damage and ulcer development. An increase in the rate of patients who fail therapy with pentavalent antimony has been documented. An adjuvant therapy w...

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Detalhes bibliográficos

Principais autores:	Maurício T. Nascimento, Ravena S. O. Cordeiro, Cayo Abreu, Camila P. Santos, Fábio Peixoto, Gabriela A. Duarte, Thiago Cardoso, Camila I. de Oliveira, Edgar M. Carvalho, Lucas P. Carvalho
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-07-01
coleção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	cutaneous leishmaniasis (CL) PPAR-γ pioglitazone inflammation monocytes
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.884237/full
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