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Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

Focal adhesions (FA) are large macromolecular assemblies which help transmit mechanical forces and regulatory signals between the extracellular matrix and an interacting cell. Two key proteins talin and vinculin connecting integrin to actomyosin networks in the cell. Both proteins bind to F-actin an...

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Auteurs principaux: Charlotte F Kelley, Thomas Litschel, Stephanie Schumacher, Dirk Dedden, Petra Schwille, Naoko Mizuno
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications Ltd 2020-07-01
Collection:eLife
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Accès en ligne:https://elifesciences.org/articles/56110
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