Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes

Abstract Background Mechanical ventilation and hyperoxia have the potential to independently promote lung injury and inflammation. Our purpose was to study both time- and dose-dependent effects of supplemental oxygen in an experimental model of mechanically ventilated mice. Methods Healthy male C57B...

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Principais autores:	Hendrik J. F. Helmerhorst, Laura R. A. Schouten, Gerry T. M. Wagenaar, Nicole P. Juffermans, Joris J. T. H. Roelofs, Marcus J. Schultz, Evert de Jonge, David J. van Westerloo
Format:	Artigo
Jezik:	Inglês
Izdano:	SpringerOpen 2017-05-01
Serija:	Intensive Care Medicine Experimental
Teme:	Hyperoxia Mechanical ventilation mice VILI Inflammation Oxygen toxicity
Online dostop:	http://link.springer.com/article/10.1186/s40635-017-0142-5
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