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Dynamic regulation of hepatic lipid metabolism by torsinA and its activators

Depletion of torsinA from hepatocytes leads to reduced liver triglyceride secretion and marked hepatic steatosis. TorsinA is an atypical ATPase that lacks intrinsic activity unless it is bound to its activator, lamina-associated polypeptide 1 (LAP1) or luminal domain–like LAP1 (LULL1). We previously...

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Principais autores: Antonio Hernandez-Ono, Yi Peng Zhao, John W. Murray, Cecilia Östlund, Michael J. Lee, Angsi Shi, William T. Dauer, Howard J. Worman, Henry N. Ginsberg, Ji-Yeon Shin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2025-05-01
Serier:JCI Insight
Fag:
Hepatology
Metabolism
Online adgang:https://doi.org/10.1172/jci.insight.175328
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