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Epimedin A inhibits the PI3K/AKT/NF-κB signalling axis and osteoclast differentiation by negatively regulating TRAF6 expression

Abstract Background Epimedin A (EA) has been shown to suppress extensive osteoclastogenesis and bone resorption, but the effects of EA remain incompletely understood. The aim of our study was to investigate the effects of EA on osteoclastogenesis and bone resorption to explore the corresponding sign...

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Principais autores: Jun Li, Jia J. Wei, Cen H. Wu, Tao Zou, Hong Zhao, Tian Q. Huo, Cheng J. Wei, Ting Yang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-08-01
coleção:Molecular Medicine
Assuntos:
Epimedin A
Osteoporosis
Osteoclastogenesis
TRAF6
PI3K/AKT/NF-κB signalling pathway
Acesso em linha:https://doi.org/10.1186/s10020-024-00893-w
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